Postgraduate Opportunities
Newcastle University
MRC PhD Studentship - To Determine the Roles of the Different Mitochondrial Respiratory Chain Complexes in the Production of Oxidative Stress and its Relationship with Mitochondrial DNA Damage and Mitochondrial Dysfunction in Aging Human Skin and Skin Cancer
Supervisors: Professor Mark Birch-Machin, Professor Calum McNeil, Dr Philip Manning
School: School of Clinical and Laboratory Sciences
Sponsor: MRC and Nu Age Medical Group Ltd (in association with remergent brand: www.remergentskin.com)
Duration: 4 years
Mitochondria are the main cellular source of reactive oxygen species (ROS) which are formed when molecular oxygen combines with free electrons as they "leak" from respiratory chain complexes. ROS are believed to be linked to the ageing process and cancer. The project addresses the relative role of individual respiratory chain complexes in relation to the "vicious cycle" components of ROS production, mitochondrial DNA damage and mitochondrial dysfunction in human skin. The research involving a unique combination of molecular/cellular biology with micro- and nano-technology techniques will be carried out in association with an industrial partner.
As part of the research training for this project, you will undertake the MRes in Medical and Molecular Biosciences.
Person specification
Applicants should hold, or expect to obtain, a first-class or upper-second-class Honours degree in any area of biological science.
Value of the award and eligibility
Due to funding criteria, this award is available to UK and other EU nationals only. The award covers fees and a stipend starting at £12,940 per annum. Non-UK EU nationals must be resident in the UK for three years prior to the start of the studentship to qualify for the full award. If they do not meet this condition, they will be eligible for a fees only award.
How to apply
You must complete the University’s postgraduate application form (http://http://www.ncl.ac.uk/postgraduate/apply/), quoting the reference number CAL28, and attaching a copy of your CV and covering letter. Select “MRes/PhD (Medical Sciences)” as the programme of study.
Closing date: 30 April 2008
Further information
The project will start in September 2008. For further information regarding this studentship please contact Professor Mark Birch-Machin, m.a.birch-machin@newcastle.ac.uk
Funding information
- Funder:
MRC
- Funding applies to:
- EU applicants (including UK)
