Funding: Fully funded PhD Project(UK/EU/International students)

Project code: PHBM4791020

Department: School of Pharmacy and Biomedical Sciences

Start dates: October 2020

Closing date: 23 February 2020

Applications are invited for a fully-funded three-year PhD to commence in October 2020.

The Project

The PhD will be based in the Faculty of Science and Health, and will be supervised by Prof Darek Gorecki and Prof Matt Guille.

This project is part of an interdisciplinary programme of research led by Profs Darek Gorecki and Matt Guille and Drs Rhiannon McGeehan and Matt Parker.

DMD gene mutations result in Duchenne Muscular Dystrophy, which gave the gene its name. However, new data from our and other laboratories indicate that DMD mutations trigger downstream multi-system abnormalities going far beyond the mechanical instability in myofibres. These alterations are diverse and affect proliferation and signalling in specific cells, mitochondrial functions and metabolism and even oncogenesis.

Moreover, cognitive deficits found in Duchenne patients are caused by distinctive molecular alterations resulting from DMD gene mutations in the brain cells. Given this increasing range of defects, identifying novel pathological mechanisms triggered by DMD mutations would advance our understanding of potential new roles of this largest human gene known in human health and disease.

The strategic aim of the three interdisciplinary PhDs is to expand DMD research into new areas by exploiting novel findings and high quality preliminary data. The projects are mutually supporting, creating the critical mass, using several animal models offering cross-species validation of findings and access to the university infrastructure across the faculties.

They also involve 10 external partners offering laboratory placements and an extensive range of expertise – so while the majority of work will be undertaken in Portsmouth, each PhD student will also spend a short period at a collaborating laboratory.

The scholarship covers tuition fees and an annual maintenance grant of £15,009 (UKRI 2019/20 rate) for three years. Scholarship recipients will also receive up to £3,000 for research project cost/consumables during the duration of the programme.

The work on this project will offer a broad-spectrum training including:

  • Molecular and functional analyses of white blood cells ex vivo
  • CRISPR/Cas9 gene editing and in vivo studies in Xenopus
  • Multi-omics analyses

Entry requirements

General admissions criteria 

You’ll need an upper second class honours degree from an internationally recognised university or a Master’s degree in an appropriate subject. In exceptional cases, we may consider equivalent professional experience and/or qualifications. English language proficiency at a minimum of IELTS band 6.5 with no component score below 6.0.

Specific candidate requirements

You would have studied one of the following subjects: cell biology, biochemistry, developmental biology, pharmacology, immunology or a related molecular area and you would be keen to learn new things.

Find out more about the project, the Supervisors and how to apply

Funding Information

Funding applies to:

Fully funded PhD Project (UK/EU/International students)

Application Deadline:

23 February 2020

Please see our website for how to apply:
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