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Deadline: 24 February 2025
Wales
Closing date: 24 February 2025
Funding providers: Swansea University (UK) Strategic Partnership Research Scholarships (SUSPRS) with Houston Methodist Research Institute (HMRI)
Subject areas: Molecular and Cellular Cardiology / Heart Failure / Systems Biology / New Therapeutics
Project start dates:
Supervisors: This is a joint PhD programme between Swansea University and Houston Methodist Research Institute (HMRI)
Aligned programmes of study: PhD Cardiovascular and Metabolic Medicine
Mode of study: Full-time
Project description:
We are looking for a talented and motivated student to join an exciting new project that takes a unique approach to tackling heart failure (HF). HF is a complex syndrome that results in the inadequate pumping of blood around the body and it compromises the length and quality of life of more than 65 million people worldwide. It has a five-year mortality rate of 50% and places a huge burden on healthcare systems (globally estimated at £280 billion rising to more than £600 billion by 2030 due to the ageing population). There is an urgent need for innovative solutions to address the current challenges in HF management. You will join a team exploring the novel concept that the human heart possesses an intrinsic memory of its cellular organisation which is a critical determinant in any functional recovery from HF.
Aims: Normal heart function depends on the intricate synchronization of billions of cells organised in complex spatial architectures. Progressive desynchronization of these cellular networks drives the normal-to-disease progression of HF. You will investigate - using deep profiling of cellular arrangements before (normal), during (disease progression) and after (recovery) functional change associated with HF – the hypothesis that the extent of functional recovery in HF is dependent on the scale of reconfiguration of the cellular network to a pre-disease memory state.
Supervisors & facilities: The project is supervised by Prof. Christopher George (Swansea University) and Prof. John Cooke (Houston Methodist Research Institute (HMRI)). It is anticipated that you will spend half of your time in HMRI which is affiliated to the Texas Medical Center, the world’s largest medical facility. You will be based in laboratories equipped with state-of-the-art tools for doing science at the interface of experimental and computational biology. You’ll learn skills in characterising HF recovery in novel pre-clinical experimental models, developing new computational frameworks for profiling cell architecture and harnessing the power of AI to visualise organisation of multicellular networks in ‘normal’, ‘failing’ and ‘recovery’ heart states.
If you’d like to join a project that transcends the conventional constraints of experimental biology and will redefine our knowledge of multicellular systems in normal, diseased and ‘recovered’ human hearts, then please send us your application. We’d love to hear from you!
For more details please see here: https://www.swansea.ac.uk/postgraduate/scholarships/research/medical-susprs-hmri-phd-molecular-and-cellular-cardiology-2025-rs777.php
Applicants must have achieved, or be expecting to achieve, a 1st class UK undergraduate degree (or equivalent international qualification), or a 2:1 UK undergraduate degree and a Distinction in a UK master’s degree (or international equivalent)
IELTS 6.5 Overall (with no individual component below 6.5) or Swansea University recognised equivalent. Full details of our English Language policy, including certificate time validity, can be found here.
Funding
Tuition fees:
Stipend:
Funds for other expenses: A travel/training allowance of £1,500 over the duration of the studentship with maximum spend of £500 in any one financial year.
To apply, please complete your application online with the following information:
*It is the responsibility of the applicant to list the above information accurately when applying, please note that applications received without the above information listed will not be considered for the scholarship award.
One application is required per individual Swansea University led research scholarship award; applications cannot be considered listing multiple Swansea University led research scholarship awards.
NOTE: Applicants for PhD/EngD/ProfD/EdD - to support our commitment to providing an environment free of discrimination and celebrating diversity at Swansea University you are required to complete an Equality, Diversity and Inclusion (EDI) Monitoring Form in addition to your programme application form.
Equality, Diversity and Inclusion (EDI) Monitoring Form (online form)
Please note that completion of the EDI Monitoring Form is mandatory; your application may not progress if this information is not submitted.
As part of your online application, you MUST upload the following documents (please do not send these via email):
For ALL scholarship applications from February 2023 an EDI (Equality, Diversity and Inclusion) Monitoring Form is required.
*External Partner Application Data Sharing – Please note that as part of the scholarship application selection process, application data sharing may occur with external partners outside of the University, when joint/co- funding of a scholarship project is applicable.
Informal enquiries are welcome; please contact Professor Christopher George (Christopher.George@Swansea.ac.uk)
The Scholarship is open to UK and international fee eligible applicants.
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