Fully Funded PhD: Analysis of the influence of selected compounds on biological ageing

This is a collaborative project between Manchester Metropolitan University and The University of Manchester Spin-Out company, Ravan Bio Ltd. Ravan Bio’s research has discovered new uses for existing approved drugs to inhibit the ageing process in mammals. The current project is to use a combination of molecular techniques, in vitro culture systems and studies in rodents to build on Ravan Bio’s findings, with the aim of refining dosimetry, regimen and the antiaging mode-of-action of the compounds under investigation. It should be noted that, apart from providing medicated feed and the taking of non-invasive samples (e.g.  cheek swabs), no other experimental procedures will be carried out on animals other than to assess their lifespan and healthspan. Manchester Metropolitan University has new labs and investments in state-of the-art technologies that the student will benefit from as well as the chance to join a thriving postgraduate student culture.         

AIMS AND OBJECTIVES

The project, using non-invasive samples from rodents, aims to understand the mechanisms of action for longevity drugs and to refine the dosimetry and regimen required to optimise these effects. Testing of epigenetic clocks, DNA damage, immune markers and cell experiments will all be used to address these questions.