Cancer and Genomics: Fully Funded SURES PhD Scholarship, Multi-OMICs approach to characterise an in vitro lung model as a predictive tool for human health (RS823)

  • DeadlineDeadline: 02 June 2025
  • WalesWales

Description

Closing date: 02 June 2025

Open to: UK applicants only

Funding Provider: Swansea University Research Excellence Scholarships (SURES): Fully Funded Scholarships in the Faculty of Medicine, Health and Life Sciences. 

Funding Period: Each scholarship is offered for a maximum period of three years; SURES students are expected to submit their theses within this timescale.  

Subject Areas: Biosciences; Cancer and Genomics

Project Start Dates: October 2025

Supervisors: Dr Laura Thomas and Prof Martin Clift

Aligned Programme of Study: Cancer and Genomics, Ph.D.

Project Description: 

It is imperative to use well characterised, human-relevant in vitro models to assess air pollution exposure impact upon human health, and how it may develop disease. However, despite the known negative association of inhalation exposure to air pollution, the mechanisms of action to which air pollution impacts lung health are currently unclear. To elucidate this, using a physiologically relevant model of the lower airways, multi-omic analyses will provide a key tool to characterise mechanistic changes and assist in predicting the human health impact of the exposure to different air pollutants. 

Aim: To use multi-omic approaches to characterise the effects of air pollutants on an established in vitro model of the human lower lung, to reveal mechanistic insights associated with lung disease development. 

Objectives: 

  1. Create realistic pollutant exposure samples representing indoor and outdoor pollutant (mixtures) using an established model of the human alveolar epithelial barrier. 
  2. Apply multi-omic approaches to assess differential gene expression and altered pathways associated with pollutant exposures, integrating this data to identify mechanisms associated with lung disease development. 

This studentship will be hosted within the medical school at Swansea University in the labs of Dr Laura Thomas (https://www.swansea.ac.uk/staff/laura.e.thomas/) and Prof Martin Clift (https://www.swansea.ac.uk/staff/m.j.d.clift/). The two research groups are based on the 4th floor of the Institute of Life Science 1 at the Singleton Campus. The groups consist of a mix of interdisciplinary academic researchers, PhD students, clinicians and computer scientists who will all support the studentship. The successful student will be further supported by members of the wider 4th floor research groups and existing industrial and academic collaborations. 

This studentship will be multi-disciplinary, working across research strengths in genomics and in vitro approaches. It is a multidisciplinary project that will train the successful student in several highly desirable skills, both in the wet-lab and in genomics approaches. We are therefore seeking an enthusiastic graduate with an interest in advanced cell models and genomics. Whilst full training will be given, previous experience with tissue culture, analysis of genomics data, bioinformatics approaches or previous use of relevant platforms such as R, are desirable.  

For informal enquiries about the project, please contact Dr Laura Thomas (laura.e.thomas@swansea.ac.uk

Interviews are expected to take place w/c 9th June. 

For more details please see here: https://www.swansea.ac.uk/postgraduate/scholarships/research/biosciences-swansea-phd-cancer-genomics-2025-rs823-.php

Entry Requirements

Due to funding restrictions, this scholarship is open to applicants eligible to pay tuition fees at the UK rate only, as defined by UKCISA regulations .

Applicants require a 1st at UG degree (Bachelor Equivalence)  

ii) OR ii) 2.1 UG degree (Bachelor Equivalence) & Masters (Distinction)  

Candidates must have achieved, or be expecting to achieve, a 1st class UK undergraduate degree (or equivalent international qualification), or a 2:1 UK undergraduate degree and a Distinction in a UK master’s degree (or international equivalent) 

  • Where applicants have multiple master’s degrees, a distinction must be held in the degree that is most relevant to the intended PhD study.
  • If you are currently studying for a master’s level qualification with an expected award date that is later than 01/10/2025, you should hold a minimum of an upper-second-class (2:1) honours degree.  
  • You should be able to demonstrate a pass with a minimum grade average of at least 70% for your part-one master’s degree modules (the taught aspect of your master’s course rather than a research-focused dissertation) and submit your dissertation by no later than 30/09/2025. 

NB: If you hold a non-UK degree, please see the Swansea University degree comparisons to find out if you meet the eligibility criteria. 2025-Country-Specific-Entry-Requirement-document-MASTER.pdf 

Applicants must be able to begin their course of study in October 2025.  As a cohort-based programme, deferral to an alternative enrolment window within the academic year or to another academic year is not permissible. 

English Language requirements: If applicable – IELTS 6.5 overall (with a score of at least 6.5 in each individual component) or equivalent that is recognised by Swansea University.  Details on the Swansea University English Language entry policy can be found here. 

Please note that both the degree and language-proficiency entry requirements for SURES are higher than the baseline standard for entry that is stipulated for most of the PhD programmes at Swansea University. 

Funding

This scholarship covers the full cost of tuition fees and an annual stipend at UKRI rate (currently £20,780 for 2025/26). 

Additional research expenses of up to £1,000 per year will also be available. 

How To Apply

To apply, please complete the entire application form here, following this link in Learner Gateway

In order to be considered for this scholarship award the following steps are also required. 

  1. In section ‘Programme Related Information’ please input the relevant RS Code for the scholarship award i.e. RS823 – SURES OMIC 
  2. In section ‘Research’ you will see ‘Proposed project title/studentship title’* (Mandatory) 

In ‘Proposed project title/studentship title’ please input either:  

  • the relevant scholarship advert link,  
  • the RS Code, or  
  • the scholarship title.   
  • Please leave Proposed Supervisor field blank 
  • Please leave Research Project (if applicable) blank 
  • In ‘Do you have a proposal to upload?*’(Mandatory) Please select Yes 
  • Then upload copy of advert (you can save the advert by clicking print, and then print to pdf) 

3.In section ‘Funding information’ please choose the option ‘Scholarship Funding’ only. Please ensure no other options are selected.  

*It is the responsibility of the applicant to list the above information accurately when applying, please note that applications received without the above information listed will not be considered for the scholarship award. 

One application is required per individual Swansea University led research scholarship award; applications cannot be considered listing multiple Swansea University led research scholarship awards. 

NOTE: Applicants for PhD/EngD/ProfD/EdD - to support our commitment to providing an environment free of discrimination and celebrating diversity at Swansea University you are required to complete an Equality, Diversity and Inclusion (EDI) Monitoring Form in addition to your programme application form.    

Please note that completion of the EDI Monitoring Form is mandatory; your application may not progress if this information is not submitted. 

As part of your online application, you MUST upload the following documents (please do not send these via email): 

  • CV 
  • Degree certificates and transcripts (if you are currently studying for a degree, screenshots of your grades to date are sufficient) 
  • A cover letter including a ‘Supplementary Personal Statement’ to explain why the position particularly matches your skills and experience and how you choose to develop the project. 
  • One reference (academic or previous employer) on headed paper or using the Swansea University reference form. Please note that we are not able to accept references received citing private email accounts, e.g. Hotmail. Referees should cite their employment email address for verification of reference. 
  • Evidence of meeting English Language requirement (if applicable). 
  • Copy of UK resident visa (if applicable) 
  • Confirmation of EDI form submission 

Informal enquiries are welcome; please contact Dr Laura Thomas (laura.e.thomas@swansea.ac.uk

*External Partner Application Data Sharing – Please note that as part of the scholarship application selection process, application data sharing may occur with external partners outside of the University, when joint/co- funding of a scholarship project is applicable. 

Who is eligible to apply?

UK applicants only

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