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Fully Funded PhD: Intergrating AI to quantify pathogenic alterations to the blood-brain-barrier in a human in vitro model

  • DeadlineDeadline: 22 July 2024
  • North West, All EnglandNorth West, All England

Description

We are looking for a talented and motivated recent graduate in Biosciences, Biomedicine, Human Genetics or related discipline to engage in an exciting new project at Manchester Metropolitan University.

The project is focused on applying state-of-the-art tools and technologies to learn how inflammatory signals traverse the blood-brain-barrier and contribute to neurodegeneration in cerebrovascular disease. You will learn from our researchers how to apply human induced Pluripotent Stem Cells (iPSC) to convolute an in vitro chip-based complex cell model of the neurovascular unit (NVU). This NVU model will be the base to then utilise lentivirally transduced genetic reporters as quantitative readouts for neuronal and glial inflammation. You will then be instructed on applying AI/machine learning protocols to spatiotemporally quantitate these multi-fluorescence outputs in the NVU model with the aim of modelling extracellular vesicle-mediated inflammation.

The project will be supported by discipline-specific experts, and you will join a team of existing post-doctoral researchers and PhD students, with access to state-of-the-art facilities and an unrivalled environment to support our graduate students. 

Entry Requirements

Recent graduate in Biosciences, Biomedicine, Human Genetics or related discipline.

Fees

This is a full-time, funded PhD opportunity in the Faculty of Science and Engineering. It is only open to home students. Home fees will be covered.

This opportunity provides an annual stipend of the research council minimum rate (set by UKRI) of £19,237 for 2024/25.

How To Apply

Interested applicants should contact Dr Tristan McKay (t.mckay@mmu.ac.uk) for an informal discussion.

To apply you will need to complete the online application form for a full-time PhD in Bioscience (or download the PGR application form).

You should also complete a CV (candidate’s choice of standard or Narrative CV) with a cover letter, addressing the project’s aims and objectives, demonstrating how the skills you have maps to the area of research and why you see this area as being of importance and interest. 

If applying online, you will need to upload your statement in the supporting documents section or email the application form and statement to PGRAdmissions@mmu.ac.uk.

Closing date: 22 July 2024

Expected start date: October 2024

Please quote the reference: SciEng-TM-2024-Blood-Brain-Barrier

Who is eligible to apply?

Home students only

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