Fully Funded PhD: Intergrating AI to quantify pathogenic alterations to the blood-brain-barrier in a human in vitro model

We are looking for a talented and motivated recent graduate in Biosciences, Biomedicine, Human Genetics or related discipline to engage in an exciting new project at Manchester Metropolitan University.

The project is focused on applying state-of-the-art tools and technologies to learn how inflammatory signals traverse the blood-brain-barrier and contribute to neurodegeneration in cerebrovascular disease. You will learn from our researchers how to apply human induced Pluripotent Stem Cells (iPSC) to convolute an in vitro chip-based complex cell model of the neurovascular unit (NVU). This NVU model will be the base to then utilise lentivirally transduced genetic reporters as quantitative readouts for neuronal and glial inflammation. You will then be instructed on applying AI/machine learning protocols to spatiotemporally quantitate these multi-fluorescence outputs in the NVU model with the aim of modelling extracellular vesicle-mediated inflammation.

The project will be supported by discipline-specific experts, and you will join a team of existing post-doctoral researchers and PhD students, with access to state-of-the-art facilities and an unrivalled environment to support our graduate students.