Fully Funded PhD: Platelet (dys)function in early pathophysiology of neurodegeneration

This PhD project explores how platelet function, which triggers blood clotting, contributes to early neurodegenerative processes, focusing on mild cognitive impairment (MCI) and potential progression to dementia. Recent findings from our research group indicate the direct effects of platelet reactivity on neurovascular function and cognitive performance in older adults. Building on this emerging evidence, this research will integrate in vitro experiments with in vivo neurovascular physiology assessments in patients with MCI.

The studentship offers a comprehensive interdisciplinary approach to studying neurodegeneration. You will use advanced imaging techniques, including functional MRI and Near-Infrared Spectroscopy, to investigate neurovascular changes, providing insights into cerebral blood flow and oxygen metabolism during cognitive tasks. Additionally, innovative in vitro models will be used to study the direct effects of platelets on neurovascular cells, examining platelet interactions with brain endothelial cells, astrocytes, and neurons. By integrating these methodologies, this research aims to identify early biomarkers of neurodegeneration and suggest new therapeutic targets.

Manchester Met is in a unique position to offer this opportunity to work with an inclusive interdisciplinary team of world leaders with access to state-of-the-art facilities. Join us to contribute to ground breaking work at the intersection of neuroscience and biology, potentially revolutionising our understanding and treatment of neurodegeneration.

Project aims and objectives

This PhD project aims to investigate the role of platelet function in the early stages of neurodegeneration, focusing on mild cognitive impairment (MCI). Through a comprehensive approach that integrates behavioural assessments, advanced imaging techniques, and innovative in vitro models, the project seeks to elucidate the mechanisms by which alterations in platelet function impact neurovascular health. By achieving the following objectives, this research will provide a detailed understanding of the potential role of platelets in early neurodegenerative processes, paving the way for novel preventive and therapeutic strategies.

Objectives:

• Assess the behavioural and cognitive implications of elevated platelet reactivity:
  • Compare platelet reactivity and cognitive performance in MCI patients and healthy controls.
  • Use clinical assessments and comprehensive cognitive tests to establish whether elevated platelet reactivity is a characteristic of early neurodegenerative pathology.
• Identify the physiological components of neurovascular function impaired in early neurodegeneration:
  • Employ advanced imaging techniques, such as functional MRI and Near-Infrared Spectroscopy, to investigate neurovascular changes in MCI patients.
  • Provide detailed insights into cerebral blood flow, oxygen metabolism, and their relationship with cognitive function during cognitive tasks.
• Explore the direct impact of platelets on neurovascular function:
  • Use in vitro neurovascular models to study interactions between platelets and brain cells, including endothelial cells, astrocytes, and neurons.
  • Relate in vitro findings to in vivo physiological parameters to understand the mechanistic effects of platelet dysfunction on neurovascular health in MCI.