Alzheimer’s disease (AD) is pathologically defined by the abnormal accumulation of extracellular proteins/peptides such as amyloid beta (Aβ) plaques and tau tangles in the brain. Recent methodological advances have enabled the development and validation of plasma biomarkers that are expected to simplify AD diagnosis. The quality and quantity of sleep, which are significantly disrupted in obstructive sleep apnoea (OSA) patients, have been associated with changes in AD biomarker levels in blood in cross-sectional studies. Furthermore, AD biomarkers have been described in the cerebrospinal fluid of sleep apnoea patients, suggesting that sleep apnoea is a potential risk factor for AD.
Project aims and objectives
This project aims to measure levels of AD biomarkers in the blood of OSA patients to assess whether these patients are at risk of developing AD and whether treating OSA symptoms, including reversing sleep fragmentation, affects AD biomarker concentrations.
To address this overall aim, the student will:
The qualifications, skills, knowledge and experience applicants should have for this project, in addition to our standard entry requirements
We are seeking a highly motivated and talented PhD candidate to undertake research exploring obstructive sleep apnoea as a modifiable risk factor for Alzheimer’s disease. The ideal candidate should meet the following criteria:
Essential qualifications
Technical and research skills
Desirable skills and experience
Additional requirements
The student will be in receipt of a stipend payment; the Research Council minimum rate (set by UKRI) is £20,780 for 2025/26.
Home and overseas students can apply. Home fees are covered. Eligible overseas students will need to make up the difference in tuition fee funding.
Please email Prof Sonia Correa-Muller (s.correa-muller@mmu.ac.uk) to discuss any questions about the project.
To apply you will need to complete the online application form for a Full-Time PhD in the Department of Life Sciences (or download the PGR application form) and submit your CV and a Cover Letter indicating how your expertise is a good fit for the project, how your experience makes you suitable for this position, and why you are interested to work in this area of research.
If applying online, you will need to upload your statement in the supporting documents section or email the application form and statement to PGRAdmissions@mmu.ac.uk.
Closing date: 27 May 2025
Expected start date: October 2025
Please quote the reference: SciEng-SCM-2025-Alzheimer
Manchester Metropolitan University fosters an inclusive culture of belonging that promotes equity and celebrates diversity. Please ensure that you take into account our Inclusive and Diverse Culture Strategy when preparing an application.
Home and overseas students can apply. Home fees are covered. Eligible overseas students will need to make up the difference in tuition fee funding.
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