Medicine: Swansea University Research Excellence Scholarships (SURES): Fully Funded PhD: The in Vivo Mechanistic Dissection of Lifespan Extension Pathways (RS569)

  • DeadlineDeadline: 10 April 2024 (23:59 GMT)
  • WalesWales

Description

Closing date: 10 April 2024 (23:59 GMT)

Fully Funded PhD Scholarship: The in vivo mechanistic dissection of lifespan extension pathways using senolytic compounds in the African Turquoise Killifish model of ageing

Funding provider: Swansea University

Subject areas: Senolytics and ageing

Project start date:

  • 1 October 2024 (Enrolment open from mid-September)

Supervisors: 

  • Dr James T. Murray (Swansea University – j.t.murray@swansea.ac.uk)
  • Professor Richard Faragher (Brighton University)

Aligned programme of study: PhD in Gerontology and Ageing Studies (Regenerative Medicine)

Mode of study: Full-time

Project description:

Swansea University is pleased to offer fully-funded Swansea University Research Excellence Scholarships (SURES) for full-time doctoral students to its fifth cohort, commencing in October 2024.

Ageing is a growing fundamental economic and social challenge since the age structure of our population will change markedly during this century. Despite significant improvements in living conditions and healthcare leading to increasing life expectancy, it is extremely rare to grow old in good health and by the age of 85 essentially no individual is disease-free.  As such, drug discovery research is focusing on potential interventions that enhance the human health span. One area of research focus is on the reversal of cellular senescence, and so there has been a rapid development of interventions that behave as senolytic drugs. One such drug is Resveratrol, a naturally occurring plant compound that is thought to reverse cellular senescence through its action on SIRT1.

The specific aim of the project is to use Resveratrol, and related senolytic compounds, to identify ageing pathways in a new in vivo model of ageing the African Turquoise Killifish (Nothobranchius furzeri). The project will investigate the effect of mid-lifespan dosing of Resveratrol and similar compounds on lifespan and ageing (senescence) markers in Killifish using RNA-seq and proteomic approaches. Once novel pathways are identified, the project will then use gene editing (CRISPR/Cas9) of Killifish to validate these novel mechanisms of senescence reversal.

This project will be a collaboration between the Murray laboratory at Swansea University, and the Faragher laboratory, at the University of Brighton.

For more details please see here: https://www.swansea.ac.uk/postgraduate/scholarships/research/medicine-sures-phd-in-vivo-2024-rs569.php

Entry Requirements

Candidates must have attained, or must be expected to attain, a first-class honours degree and/or a distinction at master’s level. If you are eligible to apply for the scholarship (i.e. a student who is eligible to pay the UK rate of tuition fees) but do not hold a UK degree, you can check our comparison entry requirements (see country specific qualifications). Please note that you may need to provide evidence of your English Language proficiency. 

  • Where applicants have multiple master’s degrees, a distinction must be held in the degree that is most relevant to the intended PhD study.
  • If you are currently studying for a master’s level qualification with an expected award date that is later than 01/10/2024, you should hold a minimum of an upper-second-class (2:1) honours degree.
  • You should be able to demonstrate a pass with a minimum grade average of at least 70% for your part-one master’s degree modules (the taught aspect of your master’s course rather than a research-focused dissertation) and submit your dissertation by no later than 30/09/2024.

Applicants must be able to begin their course of study in October 2024. As a cohort-based programme, deferral to an alternative enrolment window within the academic year or to another academic year is not permissible.

Please note that both the degree and language-proficiency entry requirements for SURES are higher than the baseline standard for entry that is stipulated for most of the PhD programmes at Swansea University. 

Due to funding restrictions, this scholarship is open to applicants eligible to pay tuition fees at the UK rate only, as defined by UKCISA regulations. 

If you have any questions regarding your academic or fee eligibility based on the above, please email pgrscholarships@swansea.ac.uk with the web-link to the scholarship(s) you are interested in.

Fees

This scholarship covers the full cost of UK tuition fees and an annual stipend at £19,237.

Additional research expenses will also be available.

How To Apply

To apply, please complete your application online with the following information:

1. Course choice – please select Gerontology and Ageing Studies / PhD / Full-time / 3 Year / October

In the event you have already applied for the above programme previously, the application system may issue a warning notice and prevent application, in this event, please email pgrscholarships@swansea.ac.uk where staff will be happy to assist you in submitting your application.

2. Start year – please select 2024
3. Funding (page 8) –

  • ‘Are you funding your studies yourself?’ – please select No
  • ‘Name of Individual or organisation providing funds for study’ – please enter ‘RS569 – SURES 5

*It is the responsibility of the applicant to list the above information accurately when applying, please note that applications received without the above information listed will not be considered for the scholarship award.

One application is required per individual Swansea University led research scholarship award; applications cannot be considered listing multiple Swansea University led research scholarship awards.

We encourage you to complete the following to support our commitment to providing an environment free of discrimination and celebrating diversity at Swansea University:

As part of your online application, you MUST upload the following documents (please do not send these via email):

  • CV
  • Degree certificates and transcripts (if you are currently studying for a degree, screenshots of your grades to date are sufficient)
  • A cover letter including a ‘Supplementary Personal Statement’ to explain why the position particularly matches your skills and experience and how you choose to develop the project.
  • Two references (academic or previous employer) on headed paper or using the Swansea University reference form. Please note that we are not able to accept references received citing private email accounts, e.g. Hotmail. Referees should cite their employment email address for verification of reference.
  • Evidence of meeting English Language requirement (if applicable).
  • Copy of UK resident visa (if applicable)
  • Confirmation of EDI form submission (optional) 

Informal enquiries are welcome, please contact Dr James T. Murray (j.t.murray@swansea.ac.uk).

*External Partner Application Data Sharing – Please note that as part of the scholarship application selection process, application data sharing may occur with external partners outside of the University, when joint/co- funding of a scholarship project is applicable.

Who is eligible to apply?

Due to funding restrictions, this scholarship is open to applicants eligible to pay tuition fees at the UK rate only, as defined by UKCISA regulations. 

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