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Deadline: 24 May 2024 (23:59 GMT)
Wales
Closing date: 24 May 2024 (23:59 GMT)
Fully Funded PhD Scholarship: The in vivo mechanistic dissection of lifespan extension pathways using senolytic compounds in the African Turquoise Killifish model of ageing
Funding provider: Swansea University
Subject areas: Senolytics and ageing
Project start date:
Supervisors:
Aligned programme of study: PhD in Gerontology and Ageing Studies (Regenerative Medicine)
Mode of study: Full-time
Project description:
Swansea University is pleased to offer fully-funded Swansea University Research Excellence Scholarships (SURES) for full-time doctoral students to its fifth cohort, commencing in October 2024.
Ageing is a growing fundamental economic and social challenge since the age structure of our population will change markedly during this century. Despite significant improvements in living conditions and healthcare leading to increasing life expectancy, it is extremely rare to grow old in good health and by the age of 85 essentially no individual is disease-free. As such, drug discovery research is focusing on potential interventions that enhance the human health span. One area of research focus is on the reversal of cellular senescence, and so there has been a rapid development of interventions that behave as senolytic drugs. One such drug is Resveratrol, a naturally occurring plant compound that is thought to reverse cellular senescence through its action on SIRT1.
The specific aim of the project is to use Resveratrol, and related senolytic compounds, to identify ageing pathways in a new in vivo model of ageing the African Turquoise Killifish (Nothobranchius furzeri). The project will investigate the effect of mid-lifespan dosing of Resveratrol and similar compounds on lifespan and ageing (senescence) markers in Killifish using RNA-seq and proteomic approaches. Once novel pathways are identified, the project will then use gene editing (CRISPR/Cas9) of Killifish to validate these novel mechanisms of senescence reversal.
This project will be a collaboration between the Murray laboratory at Swansea University, and the Faragher laboratory, at the University of Brighton.
For more details please see here: https://www.swansea.ac.uk/postgraduate/scholarships/research/medicine-sures-phd-in-vivo-2024-rs612.php
Candidates must have attained, or must be expected to attain, a first-class honours degree and/or a distinction at master’s level. If you are eligible to apply for the scholarship but do not hold a UK degree, you can check our comparison entry requirements (see country specific qualifications). Please note that you may need to provide evidence of your English Language proficiency.
Applicants must be able to begin their course of study in October 2024. As a cohort-based programme, deferral to an alternative enrolment window within the academic year or to another academic year is not permissible.
Please note that both the degree and language-proficiency entry requirements for SURES are higher than the baseline standard for entry that is stipulated for most of the PhD programmes at Swansea University.
Due to funding restrictions, this scholarship is open to applicants eligible to pay tuition fees at the UK rate only, as defined by UKCISA regulations.
If you have any questions regarding your academic or fee eligibility based on the above, please email pgrscholarships@swansea.ac.uk with the web-link to the scholarship(s) you are interested in.
This scholarship covers the full cost of UK tuition fees and an annual stipend at £19,237.
Additional research expenses will also be available.
To apply, please complete your application online with the following information:
In the event you have already applied for the above programme previously, the application system may issue a warning notice and prevent application, in this event, please email pgrscholarships@swansea.ac.uk where staff will be happy to assist you in submitting your application.
*It is the responsibility of the applicant to list the above information accurately when applying, please note that applications received without the above information listed will not be considered for the scholarship award.
One application is required per individual Swansea University led research scholarship award; applications cannot be considered listing multiple Swansea University led research scholarship awards.
We encourage you to complete the following to support our commitment to providing an environment free of discrimination and celebrating diversity at Swansea University:
As part of your online application, you MUST upload the following documents (please do not send these via e-mail). We strongly advise you to provide the listed supporting documents by the advertised application closing date. Please note that your application may not be considered without the documents listed:
Informal enquiries are welcome, please contact Dr James T. Murray (j.t.murray@swansea.ac.uk).
*External Partner Application Data Sharing – Please note that as part of the scholarship application selection process, application data sharing may occur with external partners outside of the University, when joint/co- funding of a scholarship project is applicable.
Due to funding restrictions, this scholarship is open to applicants eligible to pay tuition fees at the UK rate only, as defined by UKCISA regulations.
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