Characterising Macromolecular Machines using Integrated Mass Spectrometry Workflows

Mass spectrometry is becoming an increasingly important tool in microbiology. This advancing technology is rapidly being applied to push boundaries in our understanding of protein systems. Trained personnel who can operate and apply this state-of-the-art technology are highly sought. This PhD will provide students with hands-on training in state-of-the-art mass spectrometry techniques associated with the analysis of proteins and protein complexes for its application in a variety of biological areas.

Initially, the project will focus on colourful, fluorescent macromolecular machines within cyanobacteria. These exciting microorganisms are one of the oldest life forms on the planet and have evolved for billions of years making them really excel at what they do. They contain complex protein machines, termed phycobilisomes, that transfer light with remarkable efficiency. The project will involve using a combination of biophysical techniques combined with mass spectrometry to understand how these tiny protein machines operate with the view to using them to transmit light within solar panel devices.

In the final years, the PhD student will apply mass spectrometry to solve other exciting biological problems covering a broad range of biological topics. They will have several projects on-going side-by-side. These could include projects on molecular glue development as a novel therapeutic angle in cancer, or antibody characterisation. Thus after completion of the PhD, many career paths will be possible.

Birmingham has an excellent reputation in mass spectrometry research. Ideal applicants will have a strong background in biochemistry. Applicants do not need experience in mass spectrometry but should be quick learners and enthusiastic to learn mass spectrometry-based techniques.